et al., Clin. Pharmacol. Ther., Jun 1, 2020, doi:10.1002/cpt.1874 (Peer Reviewed) (not included in the study count)
Finding the Dose for Hydroxych loroquine Prophylaxis for COVID‐19: The Desperate Search for Effectiveness
Analysis of HC
Q dosing regimens, recommending:
PrEP: 800mg loading dose followed by 400mg 2 or 3 times weekly to maintain weekly troughs above EC50
in >50% of patients at steady-state.
PEP: 800mg loading dose followed in 6 hours by 600mg, then 600mg daily for 4 more days to achieve daily troughs above EC50
in >50% subjects.
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