Browning, D., Pharmacology of Chloroquine and Hydroxychloroquine, 2014, 35-63, doi:10.1007/978-1-4939-0597-3_2 (Peer Reviewed) (not included in the study count) Pharmacology of Chloroquine and Hydroxychloroquine
Review of the pharmacology of CQ and HCQ. Some notable points:- HCQ and CQ are equipotent but CQ is more toxic, the therapeutic ratio is higher for HCQ. - Concentrations in different tissues can vary >10x, in particular the concentration in the lung is much higher in animal experiments. - Tissue uptake as a function of dosage is nonlinear.
Browning et al., 1/1/2014, peer-reviewed, 1 author.