Analgesics
Antiandrogens
Azvudine
Bromhexine
Budesonide
Colchicine
Conv. Plasma
Curcumin
Famotidine
Favipiravir
Fluvoxamine
Hydroxychlor..
Ivermectin
Lifestyle
Melatonin
Metformin
Minerals
Molnupiravir
Monoclonals
Naso/orophar..
Nigella Sativa
Nitazoxanide
Paxlovid
Quercetin
Remdesivir
Thermotherapy
Vitamins
More

Other
Feedback
Home
Top
Results
Abstract
All vitamin D studies
Meta analysis
 
Feedback
Home
next
study
previous
study
c19early.org COVID-19 treatment researchVitamin DVitamin D (more..)
Melatonin Meta
Metformin Meta
Azvudine Meta
Bromhexine Meta Molnupiravir Meta
Budesonide Meta
Colchicine Meta
Conv. Plasma Meta Nigella Sativa Meta
Curcumin Meta Nitazoxanide Meta
Famotidine Meta Paxlovid Meta
Favipiravir Meta Quercetin Meta
Fluvoxamine Meta Remdesivir Meta
Hydroxychlor.. Meta Thermotherapy Meta
Ivermectin Meta

All Studies   Meta Analysis    Recent:   
0 0.5 1 1.5 2+ Severe case 89% Improvement Relative Risk Hospitalization time 87% Case 24% Vitamin D for COVID-19  Demir et al.  Sufficiency Are vitamin D levels associated with COVID-19 outcomes? Retrospective 210 patients in Turkey Lower severe cases (p=0.001) and shorter hospitalization (p=0.001) c19early.org Demir et al., J. Medical Virology, Jan 2021 Favors vitamin D Favors control

Vitamin D deficiency is associated with COVID-19 positivity and the severity of the disease

Demir et al., Journal of Medical Virology, doi:10.1002/jmv.26832
Jan 2021  
  Post
  Facebook
Share
  Source   PDF   All   Meta
Vitamin D for COVID-19
8th treatment shown to reduce risk in October 2020
 
*, now known with p < 0.00000000001 from 120 studies, recognized in 7 countries.
No treatment is 100% effective. Protocols combine complementary and synergistic treatments. * >10% efficacy in meta analysis with ≥3 clinical studies.
3,900+ studies for 60+ treatments. c19early.org
Retrospective cohort study of 487 patients finding that lower vitamin D levels is associated with more severe cases as measured by affected lung segments and increased hospitalization time for COVID-19 positive patients, and that lower vitamin D levels increases COVID-19 PCR+ cases.
This is the 45th of 194 COVID-19 sufficiency studies for vitamin D, which collectively show higher levels reduce risk with p<0.0000000001 (1 in 2470 vigintillion).
risk of severe case, 89.3% lower, RR 0.11, p < 0.001, high D levels 13, low D levels 99, ratio of the mean number of affected lung segments, >30ng/ml vs. <=10ng/mL.
hospitalization time, 87.1% lower, relative time 0.13, p < 0.001, high D levels 13, low D levels 99, >30ng/ml vs. <=10ng/mL.
risk of case, 24.2% lower, RR 0.76, p = 0.18, high D levels 13 of 31 (41.9%), low D levels 99 of 179 (55.3%), NNT 7.5, >30ng/ml vs. <=10ng/mL.
Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates
Demir et al., 29 Jan 2021, retrospective, Turkey, peer-reviewed, 3 authors.
This PaperVitamin DAll
Vitamin D deficiency is associated with COVID‐19 positivity and severity of the disease
Mustafa Demir, Fadime Demir, Hatice Aygun
Journal of Medical Virology, doi:10.1002/jmv.26832
The present study examined the relationship between polymerase chain reaction (PCR) test positivity and clinical outcomes of vitamin D levels measured within the 6 months before the PCR test in coronavirus disease 2019 (COVID-19)-positive patients. In this retrospective cohort study, COVID-19 (227) and non-COVID-19 patients (260) were divided into four groups according to their vitamin D levels: Group I (0-10 ng/ml), Group II (10-20 ng/ml), Group III (20-30 ng/ml), and Group IV (vitamin D > 30 ng/ml). Laboratory test results and the radiological findings were evaluated. In addition, for comparative purposes, medical records of 1200 patients who had a hospital visit in the November 1, 2019-November 1, 2020 period for complaints due to reasons not related to COVID-19 were investigated for the availability of vitamin D measurements. This search yielded 260 patients with tested vitamin D levels. Vitamin D levels were below 30 ng/ml in 94.27% of 227 COVID-19-positive patients (average age, 46.32 ± 1.24 years [range, 20-80 years] and 56.54% women) while 93.07% of 260 non-COVID-19 patients (average age, 44.63 ± 1.30 years [range, 18-75 years] and 59.50% women) had vitamin D levels below 30 ng/ml. Nevertheless, very severe vitamin D deficiency (<10 ng/ml) was considerably more common in COVID-19 patients (44%) (average age, 44.15 ± 1.89 years [range, 23-80 years] and 57.57% women) than in non-COVID-19 ones (31%) (average age, 46.50 ± 2.21 years [range, 20-75 years] and 62.5% women). Among COVID-19-positive patients, the group with vitamin D levels of >30 ng/ml had significantly lower D-dimer and C-reactive protein (CRP) levels, number levels, number of affected lung segments and shorter hospital stays. No difference was found among the groups in terms of age and gender distribution. Elevated vitamin D levels could decrease COVID-19 PCR positivity, D-dime and CRP levels and the number of affected lung segments in COVID-19-positive patients, thereby shortening the duration of hospital stays and alleviating the intensity of COVID-19.
CONFLICT OF INTERESTS The authors declare that there are no conflict of interests. AUTHOR CONTRIBUTIONS Hatice Aygun conceived and designed the research. Hatice Aygun, Fadime Demir, Mustafa Demir collected, analyzed and interpreted the data. Hatice Aygun wrote the article. All authors read and approved the manuscript.
References
Aranow, Vitamin D and the immune system, J Investig Med
Aygun, Vitamin D can prevent COVID-19 infection-induced multiple organ damage. Naunyn-Schmiedeberg, 's Arch Pharmacol
Castillo, Costa, Barrios, Effect of calcifediol treatment and best available therapy versus best available therapy on intensive care unit admission and mortality among patients hospitalized for COVID-19: A pilot randomized clinical study, J Steroid Biochem Mol Biol
Chong, Kim, Cho, Herpes simplex virus pneumonia: highresolution CT findings, Br J Radiol
Cooper, Crofts, Dinicolantonio, Relationships between hyperinsulinaemia, magnesium, vitamin D, thrombosis and COVID-19: rationale for clinical management, Open Heart
Cui, Xu, Li, Vitamin D receptor activation regulates microglia polarization and oxidative stress in spontaneously hypertensive rats and angiotensin II-exposed microglial cells: role of renin-angiotensin system, J Med Virol
D'avolio, Avataneo, Manca, 25-Hydroxyvitamin D concentrations are lower in patients with positive PCR for SARS-CoV-2, Nutrients
Dadaci, Cetinkaya, Acir, Oncel, Borazan, Serum vitamin D levels in patients with acute anterior uveitis, Ocul Immunol Inflamm
Daneshkhah, Agrawal, Eshein, Subramanian, Roy et al., Evidence for possible association of vitamin D status with cytokine storm and unregulated inflammation in COVID-19 patients, Aging Clinical and Exp Res
Daneshkhah, Agrawal, Eshein, Subramanian, Roy et al., The possible role of vitamin D in Suppressing cytokine storm and associated mortality in COVID-19 patients
De Maat, Mast, Danser, Veerdonk, Maas, October Impaired breakdown of bradykinin and its metabolites as a possible cause for pulmonary edema in COVID-19 infection, Seminar Thromb Hemostasis
Gattinoni, Coppola, Cressoni, Busana, Rossi et al., COVID-19 does lead to a "typical" acute respiratory distress syndrome, Am J Respir Crit Care Med
Grant, Lahore, Mcdonnell, Vitamin D supplementation could prevent and treat influenza, coronavirus, and pneumonia infections
Guan, Ni, Hu, Clinical characteristics of coronavirus disease 2019 in China, N Engl J Med
Hanff, Harhay, Brown, Cohen, Mohareb, Is there an association between COVID-19 mortality and the reninangiotensin system-a call for epidemiologic investigations, Clin Infect Dis
Hani, Trieu, Saab, COVID-19 pneumonia: a review of typical CT findings and differential diagnosis, Diagn Interv Imaging
Iannaccone, Scacciavillani, Buono, Weathering the cytokine storm in COVID-19: therapeutic implications, Cardiorenal Med
Ilie, Stefanescu, Smith, The role of vitamin D in the prevention of coronavirus disease 2019 infection and mortality, Aging Clin Exp Res
Karahan, Katkat, Impact of Serum 25 (OH) Vitamin D level on mortality in patients with COVID-19 in Turkey, J Nutr Health Aging
Khoo, Chai, Koenen, Joosten, Netea et al., Translating the role of vitamin D3 in infectious diseases, Crit Rev Microbiol
Levi, Van Der Poll, Coagulation and sepsis, Thromb Res
Li, Wu, Wu, The clinical and chest CT features associated with severe and critical COVID-19 pneumonia, Invest Radiol
Lips, Cashman, Lamberg-Allardt, Current vitamin D status in European and Middle East countries and strategies to prevent vitamin D defciency: a position statement of the European Calcifed Tissue Society, Eur J Endocrinol
Maghbooli, Sahraian, Ebrahimi, Vitamin D sufficiency, a serum 25-hydroxyvitamin D at least 30 ng/mL reduced risk for adverse clinical outcomes in patients with COVID-19 infection, PLOS One
Meltzer, Best, Zhang, Vokes, Arora et al., Association of vitamin D status and other clinical characteristics with COVID-19 test results, JAMA
Oudkerk, Büller, Kuijpers, Diagnosis, prevention, and treatment of thromboembolic complications in COVID-19: report of the National Institute for public health of the Netherlands, Radiology
Panichi, Pietro, Andreini, Calcitriol modulates in vivo and in vitro cytokine production: a role for intracellular calcium, Kidney Int
Rhodes, Subramanian, Laird, Kenny, Low population mortality from COVID-19 in countries south of latitude 35 degrees North supports vitamin D as a factor determining severity, Alimentary Pharmacol Ther
Salazar, Martínez, Chávez-Castillo, C-reactive protein: an in-depth look into structure, function, and regulation, Int Scholarly Res Notices
Salehi, Abedi, Balakrishnan, Gholamrezanezhad, Coronavirus disease 2019 (COVID-19): a systematic review of imaging findings in 919 Patients, Am J Roentgenol
Solak, Cihan, Mercan, Kethuda, Eryılmaz, Evaluation of 25-hydroxyvitamin D levels in Central Anatolia, Turkey, BioMed Res Int
Sparks, Crowley, Gurley, Mirotsou, Coffman, Classical renin-angiotensin system in kidney physiology, Compr Physiol
Wong, Viswanathan, Wang, Sun, Clark et al., Current and future developments in the treatment of virus-induced hypercytokinemia, Future Med Chem
Xu, Yang, Chen, Luo, Zhang et al., Vitamin D alleviates lipopolysaccharide induced acute lung injury via regulation of the renin angiotensin system, Mol Med Rep
Yuen, Ye, Fung, Chan, Jin, SARS-CoV-2 and COVID-19: the most important research questions, Cell Biosci
Zhang, Long, Xiao, Yang, Toulon et al., Use of D-dimer in oral anticoagulation therapy, Int J Lab Hematol
Zhang, Yan, Fan, D-dimer levels on admission to predict in-hospital mortality in patients with COVID-19, J Thromb Haemost
Çiçek, Kalkan, Sivri, Determination of the level of knowledge and attitudes of mothers regarding vitamin D use in Konya
Loading..
Please send us corrections, updates, or comments. c19early involves the extraction of 100,000+ datapoints from thousands of papers. Community updates help ensure high accuracy. Treatments and other interventions are complementary. All practical, effective, and safe means should be used based on risk/benefit analysis. No treatment or intervention is 100% available and effective for all current and future variants. We do not provide medical advice. Before taking any medication, consult a qualified physician who can provide personalized advice and details of risks and benefits based on your medical history and situation. FLCCC and WCH provide treatment protocols.
  or use drag and drop   
Submit