COVID-19 studies:  C19 studies: C19:  IvermectinIVM Vitamin DV.D HC QHC Q Vitamin CV.C ZincZn PVP-IPVP-I FLVFLV REGNR2 LY-CoVLY RemdesivirRMD
HCQ study #162 of 259
10/21 Late treatment study
Dubee et al., medRxiv, doi:10.1101/2020.10.19.20214940 (Preprint)
A placebo-controlled double blind trial of hydroxychloroquine in mild-to-moderate COVID-19
Source   PDF   Share   Tweet
Small early terminated late stage (60% on oxygen) RCT in France showing 46% lower mortality.
mortality at 28 days relative risk RR 0.54 [0.21-1.42]
combined mortality/intubation at 28 days relative risk RR 0.74 [0.33-1.70]
If not stopped early and the same trend continued, statistical significance would be reached on 28 day mortality after ~550 patients (1,300 patients were planned).
Mortality results are not provided for subgroups. For the subgroups receiving AZ:
HCQ+(AZ from day 0): combined mortailty/intubation RR 0.16, p = 0.21
(0/10 HCQ+AZ and 3/11 placebo, 0.5 added for calculations due to 0)
HCQ+(AZ later), combined mortality/intubation RR 0.42 [0.05-3.54]
No safety concerns were identified. This study has been presented as negative, however the results do not support that conclusion.
NCT04325893

Dubee et al., 10/21/2020, Randomized Controlled Trial, France, Europe, preprint, median age 77.0, 18 authors.
risk of death at day 28, 46.0% lower, RR 0.54, p = 0.21, treatment 6 of 124 (4.8%), control 11 of 123 (8.9%).
risk of combined intubation/death at day 28, 26.0% lower, RR 0.74, p = 0.82, treatment 9 of 124 (7.3%), control 12 of 123 (9.8%).
risk of combined intubation/death, 85.1% lower, RR 0.15, p = 0.21, treatment 0 of 10 (0.0%), control 3 of 11 (27.3%), HCQ+AZ from day 0 subgroup.

Effect extraction follows pre-specified rules prioritizing more serious outcomes. For an individual study the most serious outcome may have a smaller number of events and lower statistical signficance, however this provides the strongest evidence for the most serious outcomes when combining the results of many trials.
Details of all 259 studies    Meta analysis
Please send us corrections, updates, or comments.
Submit