Retrospective 4666 people with autoimmune or inflammatory conditions, showing HCQ adjusted risk of COVID-19 OR 0.91 [0.68-1.23]. Results are not adjusted for the significantly different risk of COVID-19 depending on the type and severity of autoimmune or inflammatory condition.
Fitzgerald et al., 2/5/2021, retrospective, USA, North America, preprint, 34 authors.
risk of COVID-19 case, 8.5% lower, RR 0.91, p = 0.52, treatment 65 of 1072 (6.1%), control 200 of 3594 (5.6%), adjusted per study, odds ratio converted to relative risk.
Effect extraction follows pre-specified rules prioritizing more serious
outcomes. For an individual study the most serious outcome may have a smaller
number of events and lower statistical signficance, however this provides the
strongest evidence for the most serious outcomes when combining the results of