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HCQ study #135 of 230
9/21 Pre-Exposure Prophylaxis study (treated before exposed to the virus)
Grau-Pujol et al., Research Square, doi:10.21203/rs.3.rs-72132/v1 (Preprint)
Pre-exposure prophylaxis with hydroxychloroquine for COVID-19: initial results of a double-blind, placebo-controlled randomized clinical trial
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Small PrEP RCT showing that PrEP with HCQ is safe at the dosage used. No deaths, hospitalizations, or serious adverse events. With only one case (in the placebo arm), efficacy was not evaluated.
The abstract appears to have a typo and does not match the results section. We believe the results section is correct with one case in the control arm - the 0.8% matches the percentage for the control arm (there is no possible number of cases for the combined arms that matches 0.8%). Note that table 2 refers to risk factors, not outcomes.

Grau-Pujol et al., 9/21/2020, Randomized Controlled Trial, Spain, Europe, preprint, 22 authors.
risk of COVID-19 case, 67.9% lower, RR 0.32, p = 0.47, treatment 0 of 142 (0.0%), control 1 of 127 (0.8%).
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