Viral load RCT finding a concentration dependent antiviral activity of oral high dose ivermectin at a dosing regimen that is well tolerated.There was no significant difference in viral load reduction between groups overall, but a significant difference in reduction was found in patients with higher median plasma ivermectin levels (72% vs. 42%, p=0.004). Decay rate was significantly greater in patients with higher median plasma ivermectin levels (0.64 vs. 0.13, p = 0.011).Mean ivermectin plasma concentration levels showed a positive correlation with viral decay rate (r = 0.46, p = 0.02).30 ivermectin patients and 15 control patients.NCT004381884