Pre-Exposure Prophylaxis study (treated before exposed to the virus)
et al., medRxiv, 10.1101/2020.05.16.20104141 (Preprint)
Similar incidence of Coronavirus Disease 2019 (COVID-19) in patients with rheumatic diseases with and without hydroxych loroquine therapy
Very small retrospective study of rheumatic disease patients, sample size is too small for statistical significance (HC Q 0.5-4.0%, no-HC Q 0.4-2.7%). Confirmed cases were 1 HC Q and 2 no-HC Q, confimed+likely cases were 1 HC Q and 3 no-HC Q. 1 HC Q and 2 no-HC Q patients were admitted to hospital. We do not think a conclusion can be drawn based on these sample sizes. Further, there are very significant differences between the groups, for example 30% of the HC Q group have SLE vs. 2.5% of the no-HC Q group. SLE patients have a 5.7 times relative risk of pneumonia according to , whereas the relative risk with glucocorticoids and TNF-α inhibitors is significantly lower . Two more recent studies with rheumatic disease/autoimmune condition patients provide higher confidence.
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