Post Exposure Prophylaxis study (treated after exposure to the virus)
et al., medRxiv, doi:10.1101/2020.08.19.20178376 (Preprint) (meta analysis - not included in study count)
Treatment and prevention of early disease before and after exposure to COVID-19 using hydroxych loroquine: A protocol for exploratory re-analysis of age and time
Analysis of Boulware et al. data showing 65% reduction in cases for treatment within 3 days, RR 0.35, p
Authors were able to obtain data on the shipping delay for participants which adds up to 3.5 days to the treatment time, so for example some "day 1" participants may actually have started treatment 4 days after reported exposure.
Restratifying shows a 65% reduction in COVID-19 when the medication was received within 3 days of the reported exposure. Authors have requested further data to improve accuracy on the time medication was received which may reduce the confidence interval.
COVID-19 case, ↓65.0%, p=0.04
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