Abd-Elsalam et al., Biological Trace Element Research, doi:10.1007/s12011-020-02512-1 (Peer Reviewed) Do Zinc Supplements Enhance the Clinical Efficacy of Hydroxychloroquine?: a Randomized, Multicenter Trial
191 patient RCT in Egypt comparing the addition of zinc to HCQ, not showing a significant difference.Clinical recovery at 28 days was 79.2% in the zinc group and 77.9% control, p = 0.969.Mechanical ventilation was used with 4 patients in the zinc group and 6 control. There were 5 deaths in each group.No information on baseline zinc values was recorded. We note that Egypt has a low rate of zinc deficiency so supplementation is less likely to be helpful in Egypt [1, 2]
Abd-Elsalam et al., 11/29/2020, peer-reviewed, 10 authors.