et al., Int. J. Infectious Diseases, doi:10.1016/j.ijid.2020.07.056 (Letter)
Q+AZ adjusted death HR 0.44, p
=0.009. Propensity scores include baseline COVID-19 disease severity, age, gender, number of comorbidities, cardio-vascular disease, duration of symptoms, date of admission, baseline plasma CRP. IPW censoring. Retrospective study of 539 COVID-19 hospitalized patients in Milan, with treatment a median of 1 day after admission. HC
Q 197 patients, HC
Q+AZ 94, control 92. Control group received various other treatments. Authors excluded people receiving other drugs which could have biased the effect of HC
Q when used in combination. Residual confounding is possible (e.g., people with CVD were more frequent in control), however people in the control group were more likely to require mechanical ventilation.
death, ↓34.0%, p=0.12
death, ↓56.0%, p=0.009, HCQ+AZ