Late treatment study
et al., Int. J. Infectious Diseases, doi:10.1016/j.ijid.2020.07.056 (Letter)
Effectiveness of Hydroxych loroquine in COVID-19 disease: A done and dusted situation?
HC Q+AZ adjusted death HR 0.44, p=0.009. Propensity scores include baseline COVID-19 disease severity, age, gender, number of comorbidities, cardio-vascular disease, duration of symptoms, date of admission, baseline plasma CRP. IPW censoring. Retrospective study of 539 COVID-19 hospitalized patients in Milan, with treatment a median of 1 day after admission. HC Q 197 patients, HC Q+AZ 94, control 92. Control group received various other treatments. Authors excluded people receiving other drugs which could have biased the effect of HC Q when used in combination. Residual confounding is possible (e.g., people with CVD were more frequent in control), however people in the control group were more likely to require mechanical ventilation.
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