6/16 Pre-Exposure Prophylaxis study (treated before exposed to the virus)
et al., Annals of the Rheumatic Diseases 2020:79, 1163-1169, doi:10.1136/annrheumdis-2020-217425 (Peer Reviewed)
Clinical characteristics of 17 patients with COVID-19 and systemic autoimmune diseases: a retrospective study
Clinical characteristics of 17 patients with COVID-19 and systemic autoimmune diseases: a retrospective study
Analysis of 1255 COVID-19 patients in Wuhan Tongji Hospital finding 0.61% with systemic autoimmune diseases, much lower than authors expected (3%–10%). Authors hypothesise that protective factors, such as CQ/HCQ use, reduce hospitalization.
Effect extraction follows pre-specified rules prioritizing more serious outcomes. For an individual study the most serious outcome may have a smaller number of events and lower statistical signficance, however this provides the strongest evidence for the most serious outcomes when combining the results of many trials.
Huang et al., 6/16/2020, retrospective, China, Asia, peer-reviewed, 15 authors.
risk of hospitalization, 80.0% lower, RR 0.20, p < 0.001, treatment 8, control 1247.
Effect extraction follows pre-specified rules prioritizing more serious outcomes. For an individual study the most serious outcome may have a smaller number of events and lower statistical signficance, however this provides the strongest evidence for the most serious outcomes when combining the results of many trials.
