Real-world evidence with a retrospective cohort of 15,968 COVID-19 hospitalized patients suggests 21 new effective treatments

{ 'DOI': '10.1186/s12985-023-02195-9', 'ISSN': ['1743-422X'], 'URL': 'http://dx.doi.org/10.1186/s12985-023-02195-9', 'abstract': '<jats:title>Abstract</jats:title><jats:sec>\n' ' <jats:title>Purpose</jats:title>\n' ' <jats:p>Despite the extensive vaccination campaigns in many countries, ' 'COVID-19 is still a major worldwide health problem because of its associated morbidity and ' 'mortality. Therefore, finding efficient treatments as fast as possible is a pressing need. ' 'Drug repurposing constitutes a convenient alternative when the need for new drugs in an ' 'unexpected medical scenario is urgent, as is the case with COVID-19.</jats:p>\n' ' </jats:sec><jats:sec>\n' ' <jats:title>Methods</jats:title>\n' ' <jats:p>Using data from a central registry of electronic health records (the ' 'Andalusian Population Health Database), the effect of prior consumption of drugs for other ' 'indications previous to the hospitalization with respect to patient outcomes, including ' 'survival and lymphocyte progression, was studied on a retrospective cohort of 15,968 ' 'individuals, comprising all COVID-19 patients hospitalized in Andalusia between January and ' 'November 2020.</jats:p>\n' ' </jats:sec><jats:sec>\n' ' <jats:title>Results</jats:title>\n' ' <jats:p>Covariate-adjusted hazard ratios and analysis of lymphocyte ' 'progression curves support a significant association between consumption of 21 different ' 'drugs and better patient survival. Contrarily, one drug, furosemide, displayed a significant ' 'increase in patient mortality.</jats:p>\n' ' </jats:sec><jats:sec>\n' ' <jats:title>Conclusions</jats:title>\n' ' <jats:p>In this study we have taken advantage of the availability of a ' 'regional clinical database to study the effect of drugs, which patients were taking for other ' 'indications, on their survival. The large size of the database allowed us to control ' 'covariates effectively.</jats:p>\n' ' </jats:sec>', 'alternative-id': ['2195'], 'article-number': '226', 'assertion': [ { 'group': {'label': 'Article History', 'name': 'ArticleHistory'}, 'label': 'Received', 'name': 'received', 'order': 1, 'value': '6 December 2022'}, { 'group': {'label': 'Article History', 'name': 'ArticleHistory'}, 'label': 'Accepted', 'name': 'accepted', 'order': 2, 'value': '27 September 2023'}, { 'group': {'label': 'Article History', 'name': 'ArticleHistory'}, 'label': 'First Online', 'name': 'first_online', 'order': 3, 'value': '6 October 2023'}, {'group': {'label': 'Declarations', 'name': 'EthicsHeading'}, 'name': 'Ethics', 'order': 1}, { 'group': {'label': 'Competing interests', 'name': 'EthicsHeading'}, 'name': 'Ethics', 'order': 2, 'value': 'The authors declare no competing interests.'}, { 'group': {'label': 'Ethics approval', 'name': 'EthicsHeading'}, 'name': 'Ethics', 'order': 3, 'value': 'This project was reviewed and approved by the Ethics Committee for the ' 'Coordination of Biomedical Research in Andalusia (29th September, 2020, Acta ' '09/20).'}, { 'group': {'label': 'Conflict of interest', 'name': 'EthicsHeading'}, 'name': 'Ethics', 'order': 4, 'value': 'The authors have no competing interests to declare that are relevant to the ' 'content of this article.'}], 'author': [ { 'ORCID': 'http://orcid.org/0000-0001-9598-6965', 'affiliation': [], 'authenticated-orcid': False, 'family': 'Loucera', 'given': 'Carlos', 'sequence': 'first'}, { 'ORCID': 'http://orcid.org/0000-0002-4235-2886', 'affiliation': [], 'authenticated-orcid': False, 'family': 'Carmona', 'given': 'Rosario', 'sequence': 'additional'}, { 'ORCID': 'http://orcid.org/0000-0003-2632-9587', 'affiliation': [], 'authenticated-orcid': False, 'family': 'Esteban-Medina', 'given': 'Marina', 'sequence': 'additional'}, { 'ORCID': 'http://orcid.org/0000-0002-1690-6347', 'affiliation': [], 'authenticated-orcid': False, 'family': 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