Early terminated very late stage (65% on supplemental oxygen) RCT with 242 HC
Q and 237 control patients not showing a significant difference, 28 day mortality adjusted odds ratio aOR 0.93 [0.48-1.85].
For the subgroup not on supplemental oxygen at baseline (relatively early treatment), the odds ratio for the 7 point outcome scale is:
aOR 0.61 [0.34-1.08]
Dosage may be too low:
Dose in first 24 hours - 1g (compare to Boulware et al. 2g)
Dose in 5 days - 2.4g (compare to Boulware et al. 3.8g)
Note the paper reports values with OR>1 favoring HC
Q, we have converted to OR<1 favoring HC
Q. Subgroup analysis is in the supplemental appendix.
death, ↓7.0%, p=0.84